Mycosis Fungoides – A disease in which a type of white blood cell (lymphocytes) become malignant (cancerous) and affect the skin. It is a type of cutaneous T-cell lymphoma.
What is Mycosis Fungoides?Mycosis fungicides are malignant T-cell lymphocytes that affect the skin. T-cell lymphocytes that help B-lymphocytes make the antibodies that help fight infection. Mycosis fungoides and the Sezary syndrome are the two most common types of cutaneous T-cell lymphoma (a type of non-Hodgkin lymphoma). Sezary syndrome occurs when the T-cell lymphocytes can also be found in the blood.
SymptomsMycosis fungoides may go through the following phases: Premycotic phase: A scaly, red rash in areas of the body that usually are not exposed to the sun. This rash does not cause symptoms and may last for months or years. It is hard to diagnose the rash as mycosis fungoides during this phase. Patch phase: Thin, reddened, eczema -like rash. Plaque phase: Small raised bumps (papules) or hardened lesions on the skin, which may be reddened. Tumor phase: Tumors form on the skin. These tumors may develop ulcers and the skin may get infected.
DiagnosisTests that examine the skin are used to detect (find) and diagnose mycosis fungoides. Physical exam and history : An exam of the body to check general signs of health, including checking for signs of disease, such as lumps, the number and type of skin lesions, or anything else that seems unusual.
- Complete blood count with differential
- Complete blood count (CBC)
- Peripheral blood smear
- Skin biopsy
- T-cell receptor (TCR) gene rearrangement test
- Flow cytometry
- Chest x-ray
- CT scan (CAT scan)
- PET scan (positron emission tomography scan)
- Lymph node biopsy : The removal of all or part of a lymph node. A pathologist views the tissue under a microscope to look for cancer cells.
- Bone marrow aspiration and biopsy