Cerubidine – Daunorubicin

What is Cerubidine?

Daunorubicin (Cerubidine) is an anthracycline chemotherapy medication. It is used to treat acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). Daunorubicin prevents DNA repair in the cell by blocking an enzyme known as topoisomerase II; this ultimately leads to cell death.

How it is administered:

Daunorubicin is administered intravenously, directly into the bloodstream as a “push.” It is not diluted into a solution prior to administration. This intravenous “push” usually takes 5 minutes approximately. Daunorubicin can be nauseating, thus pre-medications are given prior to infusion to help prevent this from occurring. Additionally, prior to starting therapy, a thorough check-up of the heart is performed as this medication can cause heart damage.

What to expect:

Daunorubicin can cause anemia and reduce the body’s ability to fight infections. Additionally, it can be nauseating; medications are typically prescribed to have on hand at home to help manage this symptom. Other side effects include hair loss, discoloration of bodily fluids, upset stomach, vomiting, diarrhea, heart damage, infertility and elevated levels of uric acid.