What is Dacarbazine?

Dacarbazine (DTIC) is an alkylating chemotherapy medication that is used to treat Hodgkin lymphoma and malignant melanoma. It can be used to treat soft tissue sarcoma; however, this is an off-label non-FDA approved indication. This medication works by breaking DNA double strands, which ultimately leads to cell death.

How it is administered:

Dacarbazine is typically administered over 60 to 90 minutes. Pain and irritation at the infusion site can occur during the administration of this medication. Additionally, this medication is a very nauseating medication; thus, pre-medications will be given prior to the start of treatment.

What to expect:

Dacarbazine can cause anemia and reduce the body’s ability to fight infections. Hair loss, skin changes, facial numbness and elevations in liver enzymes are common side effects. Nausea and vomiting are very common as well. Medications are prescribed to have on hand at home to help treat and prevent nausea. Additionally, weight loss can occur; maintaining proper nutrition is essential in helping reduce the amount of weight lost.