Emend IV- Fosaprepitant

What is Fosaprepitant?

Fosaprepitant (Emend IV) is an antiemetic medication; it is Substance-P/ Neurokinin 1 receptor antagonist. It is used in the prevention of acute and delayed nausea and vomiting associated with moderately and highly- emetogenic chemotherapy. It is used with other anti-nausea medications, as it increases the activity of other commonly used anti-nausea medications. This medication blocks the Substance-P/ Neurokinin 1receptor.

How is it administered?

Fosaprepitant is infused intravenously over 20 to 30 minutes. It is given at least 30 minutes before the start of chemotherapy infusion/administration. This medication is a common “pre-medication,” especially for regimens that are known to be highly nauseating.

What to expect:

Overall, this medication is typically well tolerated. Some common side effects include: fatigue, headache, infusion site redness and hiccups. Rarely, shortness of breath can occur during infusion. As with any medication, some people may develop hyper-sensitivities.