Rubex – Doxorubicin
Patient Education Quick Reference Guide Diablo Valley Oncology/Hematology Medical Group Phone Number: 925-677-5041Description This medication is used to treat:
- breast cancer
- ovarian cancer
- transitional cell bladder cancer
- bronchogenic lung cancer
- thyroid cancer
- gastric cancer
- soft tissue and osteogenic sarcomas
- Wilms’ tumor
- malignant lymphoma (Hodgkin’s and non-Hodgkin’s)
- acute myeloblastic leukemia
- acute lymphoblastic leukemia
- Kaposi’s sarcoma related to acquired immunodeficiency syndrome (AIDS)
Other uses for this medicineDoxorubicin is also used to treat Ewing’s tumor; squamous cell carcinomas of the head, neck, cervix, and vagina; carcinomas of the testes, prostate, and uterus; and refractory multiple myeloma. Talk to your doctor about the possible risks of using this drug for your condition.
What special precautions should I follow?Before taking doxorubicin:
- tell your doctor and pharmacist if you are allergic to doxorubicin or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially those listed in the IMPORTANT WARNING section, actinomycin D (Cosmegen), aspirin, cyclosporine (Neoral, Sandimmune), paclitaxel (Taxol), phenobarbitol (Barbital), phenytoin (Dilantin), progesterone injection, verapamil (Calan, Covera, Verelan), streptozocin (Zanosar), and vitamins.
- in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had kidney disease.
- you should know that doxorubicin may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. However, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breast-feeding should tell their doctors before they begin taking this drug. You should not plan to have children while receiving chemotherapy or for a while after treatments. (Talk to your doctor for further details.) Use a reliable method of birth control to prevent pregnancy. Doxorubicin may harm the fetus.
- do not have any vaccinations (e.g., measles or flu shots) without talking to your doctor.
What side effects can this medication cause?Side effects from doxorubicin are common and include:
- nausea and vomiting which may last up to 24-48 hours after treatment
- loss of appetite
- difficulty swallowing
- thinned or brittle hair
- skin irritation (sunburn-like) or rash on areas previously exposed to radiation treatments
- darkening of fingernails or toenails
- swelling, pain, redness, or peeling of skin on the palms and soles of the feet
- mouth blistering
- unusual bruising or bleeding
- red urine or sweat
- pain at the injection site
- persistent diarrhea or any change in normal bowel habits for more than 2 days
- sore throat
- breathing discomfort
In case of emergency/overdoseIn case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Other names
- Liposomal doxorubicin
- Doxorubicin can cause a decrease in the number of blood cells in your bone marrow. Prolonged use of doxorubicin can also cause severe heart damage, even years after you have stopped taking doxorubicin. The risk of heart damage after stopping doxorubicin is higher in children.
- Tell your doctor if you have ever had chemotherapy with daunorubicin (Cerubidine, DaunoXome), doxorubicin, idarubicin (Idamycin), or radiation therapy to the chest and if you have or have had heart or liver disease. Tell your doctor if you are taking cyclophosphamide (Cytoxan, Neosar) or mitoxantrone (Novantrone).
- If you experience any of the following symptoms, call your doctor immediately: back pain, flushing, or chest tightness. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to doxorubicin.
- When doxorubicin is administered into a vein, it may leak into surrounding tissue. Your doctor or health care provider will monitor your administration site for this reaction.
- Talk to your doctor about the risks of taking doxorubicin.