Vectibix-Panitumumab

Patient Education Quick Reference Guide Diablo Valley Oncology/Hematology Medical Group Phone Number: 925-677-5041

WARNING Side effects involving the skin were reported in 89% of patients. In 12% of patients receiving panitumumab alone, these side effects were severe. The skin problems reported included acne, itching, redness, rash, peeling, infection in the skin around the fingernails, cracking of the skin. Severe skin-related side effects developed into severe infections, sometimes causing death. Infusion related reactions: Severe infusion reactions occurred when panitumumab was given in approximately 1% of patients. Reports of severe infusion reactions included severe allergic reaction (anaphylaxis), tightness in the lungs (bronchospasm), fever, chills, and hypotension (low blood pressure). Your doctor or healthcare provider will watch you carefully during and after the administration of panitumumab to make sure that you do not experience any reactions. Uses For This Medication
  • Panitumumab is used in the treatment of EGFR-expressing, metastatic colorectal carcinoma that continues to worsen, or progress, during or after treatment with fluoropyrimidine, oxaliplatin, and irinotecan.
  • This medication may also be given for other conditions as determined by your doctor.
  How This Medication Works Panitumumab is a monoclonal antibody. Monoclonal antibodies are a new kind of treatment known as “targeted therapy” that is different from traditional chemotherapy. Most chemotherapy medications work by killing rapidly dividing cells in the body. Monoclonal antibodies work by binding to (targeting) and killing only certain cells. Benefits Of This Medication In patients with advanced colorectal cancer, panitumumab, when given as a single agent can shrink the size of some tumors and can slow the progression of the disease. It is not yet known whether panitumumab can lengthen the lives of patients with colorectal cancer or whether it can decrease the symptoms caused by the disease. Precautions to be Aware of Before Taking This Medication

Organ related precautions

  • Rarely, a serious lung problem known as pulmonary fibrosis, has been reported in people taking this medication. Contact your doctor or healthcare provider immediately if you experience symptoms such as a shortness of breath, cough, or fever. These symptoms can get worse quickly and may require hospitalization. Make sure that your doctor or healthcare provider is aware if you have any lung problems before starting this medication.
  • Skin related problems have been reported with panitumumab, including an acne-like rash, drying of the skin, and cracking of the skin, especially on the face, neck, and trunk of the body. In some cases, these skin problems were very serious and in rare cases fatal. If you develop a rash or any other skin changes, let your doctor or healthcare provider know. In addition, since the sun can worsen these skin problems, you should stay out ofdirect sunlight, wear protective clothing (for example long pants, long-sleeved shirt, hat) and sunglasses, and apply a sun-block product that has a skin protection factor (SPF) of at least 15 to your skin and lips.
 

Miscellaneous precautions

  • You should let your doctor or healthcare provider know if you are allergic to panitumumab, or any of its components.
  • This medication may cause your blood magnesium level to decrease. Your doctor or healthcare provider may check your blood to watch for this problem.
  • Do not receive any immunizations (vaccinations) while on this medication without your doctor or healthcare provider’s approval. This medication can increase your risk of infection. For certain immunizations, you may develop the infection that the immunization is intended to prevent.
 

Patient specific precautions

  • It is not known if this medication is safe and effective in children.
 

Pregnancy and breastfeeding precautions

When taking this medication, you should use effective birth control to prevent pregnancy. Tell your doctor or healthcare provider right away if you or your spouse/partner becomes pregnant since this medication may cause fetal harm. It is not known whether this medication is found or excreted in breast milk. Since many medications are excreted in breast milk and because this medication can cause serious harmful reactions in infants, breastfeeding should be avoided. Many anti-cancer therapies can cause sterility. Notify your doctor or healthcare provider if you want to have children in the future.

Medication And Food Interactions

Before using this medication, tell your doctor or healthcare provider of all prescription or over-the-counter products you are taking, including dietary supplements or vitamins, herbal medicines and homeopathic remedies. Do not start or stop any medication without your doctor or healthcare provider’s approval.
  • It is not known whether this medication interacts with other medications you are taking.
  Side Effects
  • All medications can cause side effects. However, not all patients will experience these side effects. In addition, other side effects not listed can also occur in some patients. You should call your doctor or healthcare provider if you have any questions or concerns while you are on this medication.
  • You should contact your doctor or healthcare provider if you experience any side effect(s) which don’t go away, worsen, are serious in nature, or are worrisome to you.
  • Side effects can occur when panitumumab is given alone or together with other chemotherapy medications.
The side effects listed below are those reported in patients who were treated with panitumumab alone.  

More common side effects

  • Feeling tired and weak, headache
  • Acne-like rash (see Warning and Precautions To Be Aware Of Before Taking This Medication)
  • Itching, peeling, and redness of the skin, (see Warning and Precautions To Be Aware Of Before Taking This Medication)
  • Fever
  • Nausea, constipation, diarrhea, stomach pain
  • Low magnesium levels
  • Inflammation and/or infection of the skin around the finger or toe nails
 

Less common side effects

  • Vomiting
  • Body swelling
  • Cough
  • Dry cracked skin
  • Acne
  • Eye disorders
  • Decreased calcium levels
 

Rare side effects

This is not a complete list of the rare side effects reported with panitumumab. For a complete list, please talk with your doctor or healthcare provider about reviewing a copy of the package insert.
  • Excessive growth of eyelashes
  • Lung problems, including pulmonary fibrosis (see Precautions To Be Aware Of Before Taking This Medication) and blood clots in the lungs
  • Mouth sores
  • Inflammation of the mouth and lining of the gastrointestinal tract
  • Eye problems including infection, excessive eye tearing, eyelid irritation
  How To Take This Medication
  • This medication is given by injection into a vein (IV) over 60 minutes by a healthcare professional. This medication can be given in different doses depending on your weight.
  • In the unlikely event of an overdose of this medication contact your doctor, your local poison control center at 1-800-222-1222, or emergency services immediately.
  Proper Storage
  • It is unlikely that you will need to store this medication. However, in the event that you do, the unopened containers should be stored (specifics for each drug).
  • Keep this medication out of the reach of children or pets.
  • Ask your doctor or healthcare provider how to dispose of any medication that you no longer use.